Our Research
Our research group is focused on Supramolecular and Organic Chemistry, with a keen attention to supramolecular catalysis, self-assembly, molecular recognition, sensing, and biological applications. Inspired by the intricate systems found in Nature, we design and study macrocyclic compounds such as calixarenes, resorcinarenes, prismarenes, and their derivatives. These structures serve as innovative platforms for exploring supramolecular functions and processes, including catalysis in confined spaces and the inhibition of proteins associated with various pathologies. Additionally, we focus on the molecular recognition and sensing of pollutants in aqueous environments.
In recent years, our research has expanded into the sustainable transformation of biomass into valuable chemicals for industrial applications. We are actively engaged in pioneering research that leverages biomass valorisation for various industries, including leather tanning and agriculture. Our mission is clear: to convert biomass-derived resources into high-value chemical products that support and enhance industrial processes.
We are passionate about pushing the boundaries of chemistry to create solutions that are not only innovative but also sustainable and impactful, bridging the gap between fundamental science and practical applications.
Synthesis of New Macrocycles
Molecular Recognition & Sensing
Supramolecular Catalysis in Confined Spaces
Sustainable Leather Technologies
Green Chemistry & Biomass Valorization
Synthesis of New Macrocycles
This research activity focuses on the rational design and synthesis of novel macrocycles and their derivatives for various applications. In addition to classical macrocycles such as resorcinarenes and calixarenes, our group has achieved significant results by studying new macrocycles like prismarenes. Among the most explored applications, supramolecular catalysis and molecular recognition have received considerable attention. Numerous studies have been conducted on the synthesis of macrocycles for biological applications, such as anticancer and antimicrobial agents, leveraging the multivalent effect.
Molecular Recognition & Sensing
Our group conducts in-depth studies on the non-covalent interactions between “host” and “guest” molecules to uncover the fundamental principles of molecular recognition. This understanding is essential for developing highly selective chemical sensors. A practical example of this research is the PrismSens project, which utilizes water-soluble prismarene derivatives for the efficient and specific capture and sensing of environmental pollutants in water.
Supramolecular Catalysis in Confined Spaces
In this field, our group has been particularly active in studying organic reactions within nanoconfined environments. By mimicking the operating principles of enzymes, we confine the reactants, allowing them to undergo reactions that lead to regio- and stereochemical outcomes distinct from those observed in bulk solvent reactions. Among the systems we have investigated are, the resorcinarene capsule developed in the CAGED project and water-soluble prismarene macrocycles.
Sustainable Leather Technologies
This topic represents an applied research area in collaboration with industry aimed at innovating production processes to enhance sustainability. The objective is to develop tanning technologies that reduce the use of harmful chemicals and minimize the overall environmental impact of the sector. This research is conducted within the framework of industrial Ph.D. programs and in partnership with local chemical and tanning companies.
Green Chemistry & Biomass Valorization
Through projects like BioVaNaMaDES, PhD SDC (Sustainable Development and Climate Change), and AGRITECH, our group focuses on the valorization of biomass and its transformation into high-value chemical products. We utilize sustainable extraction processes, deep eutectic solvents (DES), and promote a circular and sustainable economy.